Mission Trail Baptist Hospital was constructed on a 28-acre greenfield site on the south side of San Antonio, property once owned by the United States Air Force (Brooks City-Base). This undeveloped property was the perfect choice when the Baptist Health System of San Antonio, a system owned by the Vanguard Health System, decided to replace its existing facility.

Mission Trail Baptist Hospital is a three-story, 110-bed replacement hospital. The facility is approximately 213,000 sq ft, with provisions made for three future floors and an additional 150 patient beds. The hospital was built based on an evidence-based design, intended to foster a patient-centric, optimal healing environment. As part of this effort, the hospital includes all private patient rooms with access to natural light and views; noise reduction features; a meditation garden; and adequate space for families to stay overnight.

The hospital provides cardiac services, mother and baby care, minimally invasive surgery, emergency and intensive care, a dialysis unit, orthopedics, urology, and vascular health care services.